Global Virology II - HIV and NeuroAIDS

Description

This book on NeuroAIDS, a collection of chapters written by experts and specialists from around the world, provides a global perspective on HIV and NeuroAIDS in the field, clinic, and laboratory. The chapters address the comorbidity of HIV and other infectious agents, including Zika virus, Ebola, Chagas disease, TB and HCV. Also discussed are key topics, such as: · Molecular socioepidemiology · Global HIV and NeuroAIDS · Neuropathology · cART and blood-brain barrier penetration · HIV replicative oscillations · HIV and SIV evolution · Psychiatric comorbidities · Neurosyphilis · The examination of current and innovative models of translational research to translational effectiveness Front Matter ....Pages i-xii Multidisciplinary Approach to HIV/AIDS: Historical Perspective (Clyde B. McCoy, A. Jeanene Bengoa, Duane C. McBride, Brian T. Foley, Shikha Puri, Alejandro J. Mendez et al.)....Pages 1-20 Global Issues in NeuroAIDS (Jennifer Massey, Bruce Brew)....Pages 21-42 HIV-1 Related Central Nervous System Diseases: Pathogenesis, Diagnosis, and Treatment – An Indian Scenario (Sudharsana Sundarrajan, Sajitha Lulu, Mohanapriya Arumugam)....Pages 43-53 HIV-1 Diversity in Brazil (Rodrigo Pessôa, Sabri Saeed Sanabani)....Pages 55-70 HIV and SIV Evolution (Brian T. Foley)....Pages 71-92 Human Brain Imaging in HIV and NeuroAIDS (Mona A. Mohamed)....Pages 93-109 HIV Neuroinvasion (Suzanne Gartner, Yiling Liu)....Pages 111-142 Neuropathology of HIV-1 Disease (Virawudh Soontornniyomkij)....Pages 143-208 HIV-Related Peripheral Nervous System Illness (Jocelyn Jiao, David M. Simpson, Jessica Robinson-Papp)....Pages 209-227 The Role of Early Life Programming in Vulnerability and Resilience in Relation to HIV (Luba Sominsky, Deborah Hodgson)....Pages 229-256 Neurocognition in Viral Suppressed HIV-Infected Children (Claudia S. Crowell, Kathleen Malee)....Pages 257-282 Psychiatric Comorbidities in HIV Infection (April D. Thames, Jacob D. Jones)....Pages 283-313 Toward an Iterative Approach to Preventing HIV Risk Among Young MSM (J. Bryan Page)....Pages 315-324 NeuroAIDS in Drug Abusers: Associations with Oral Manifestations (Fariba S. Younai)....Pages 325-345 Socioepidemiology of Injection Drug Users in Miami and HIV-1B Envelope (V1–V5) Genetic Diversity: A Preliminary Study (Paul Shapshak, Brian T. Foley, Seetharaman Balaji, David M. Segal, Clyde McCoy, J. Bryan Page)....Pages 347-373 The Persistence of HIV-Associated Neurocognitive Disorder (HAND) in the Era of Combined Antiretroviral Therapy (cART) (Elyse J. Singer, Natasha M. Nemanim)....Pages 375-403 Antiretroviral Therapy: Brain Penetration (Charurut Somboonwit, Jose A. Montero, John T. Sinnott, Paul Shapshak)....Pages 405-434 Molecular Mechanisms of Cognitive Impairment in Patients with HIV Infection: Application of Bioinformatics and Data Mining (Luca Giacomelli, Francesco Chiappelli, Bruno Orlando, Victor Sivozhelezov, Roberto Eggenhöffner)....Pages 435-444 Genetic, Epigenetic, and Transcriptomic Studies of NeuroAIDS (Andrew J. Levine, Kumud K. Singh, Asha R. Kallianpur)....Pages 445-518 NeuroAIDS: A Review of Gene Expression in Neurons, Astrocytes, and Oligodendrocytes (Jeanie McGee, Alireza Minagar)....Pages 519-532 Neuronal Apoptotic Pathways in HIV-Associated Dementia, Alzheimer’s Disease, Parkinson’s Disease, and Huntington’s Disease (Fatten F. Elkomy, Andrew J. Levine, Elyse Singer, Charurut Somboonwit, Todd Wills, Kaley Tash et al.)....Pages 533-578 Clinical Relevance of Humanized Mice (Rachel Samantha Resop, Irene Jane Kim, Huy Nguyen, Dimitrios Nikolaos Vatakis)....Pages 579-599 HIV and Stroke (Souvik Sen, Lauren Giamberardino, Parth Thakker)....Pages 601-623 Hepatitis C and HIV Neurological Implications (Shuchi Pandya, Misbahuddin Syed, Manuel Castro, Jamie P. Morano, Beata Casanas)....Pages 625-643 Central Nervous System Reactivation of Chagas Disease in Immunocompromised Patients with HIV/AIDS (Silvana Maria Eloi-Santos, Unai Tupinambás, Helena Duani, Jose Eymard Homem Pittella)....Pages 645-657 Central Nervous System Tuberculosis (Beata Casanas, Douglas Holt, Kelly Kynaston)....Pages 659-674 Neurosyphilis and HIV Infection (Anteneh Addisu, Beata Casanas, Sally Alrabaa)....Pages 675-687 Orthopoxviruses and Human Disease (Robert Castro, Beata Casanas)....Pages 689-697 Opportunistic Neurologic Infections in Patients Infected with Human Immunodeficiency Virus (Kelly Kynaston, Minh Ho, Robert Castro, Jose A. Montero)....Pages 699-729 Zika Virus and HIV/AIDS (A. Jeanene Bengoa, Clyde B. McCoy, Brian T. Foley, Shikha Puri, Alejandro J. Mendez, Paul Shapshak)....Pages 731-750 Global Convergent Translational Science for Neuro-involvement in Ebola Viral Disease: Lessons Learned from Neuro-AIDS (Francesco Chiappelli, Allen M. Khakshooy, Andre Barkhordarian, Vandan R. Kasar, Melissa Nahcivan, Mia T. Nguyen et al.)....Pages 751-777 Sequence Accuracy in Primary Databases: A Case Study on HIV-1B (Balaji Seetharaman, Akash Ramachandran, Krittika Nandy, Paul Shapshak)....Pages 779-822 Amyloidogenic Pattern Prediction of HIV-1 Proteins (Patil Sneha, Balaji Seetharaman, Paul Shapshak)....Pages 823-895 On the Potential for Multiscale Oscillatory Behavior in HIV (Alexander V. Ratushny, Patrick De Leenheer, Sergei I. Bazhan, Gennady A. Bocharov, Tamara M. Khlebodarova, Vitaly A. Likhoshvai)....Pages 897-924 Short Oligopeptide T-Cell Epitopes in HIV-1/AIDS Vaccine Development: Current Status, Design, Promises and Challenges (Pandjassarame Kangueane, Kumar Viswapoorani, Christina Nilofer, Subramani Manimegalai, Murugan Sivagamy, Uma Kangueane et al.)....Pages 925-938 HIV-1 Envelope (ENV) GP160 Trimer Protein Complex SPIKE as a Recombinant Macromolecular Assembly Vaccine Component Candidate: Current Opinion (Christina Nilofer, Arumugam Mohanapriya, Pandjassarame Kangueane)....Pages 939-951 Gene Therapy Blueprints for NeuroAIDS (Hector E. Rodriguez, Seetha Lakshmi, Charurut Somboonwit, Asa Oxner, Lucy Guerra, Anteneh Addisu et al.)....Pages 953-993 Biostatistical Concerns in HIV Research (Robert C. Duncan)....Pages 995-1041 Back Matter ....Pages 1043-1067