Next-Generation Biomaterials for Bone & Periodontal Regeneration

Description

Cover Half Title Page Library of Congress Cataloging-in-Publication Data Title Page Contents Dedication Preface Acknowledgments Contributors 01: The Regenerative Properties of Bone Grafts: A Comparison Between Autografts, Allografts, Xenografts, and Alloplasts Summary Bone Regeneration Autografts Allografts Xenografts Alloplasts Proportional Use of Bone Grafting Materials Regenerative Properties of Autografts, Allografts, Xenografts, and Synthetic Alloplasts Conclusion References 02: Autogenous Bone: The GoldStandard for Bone Regeneration Summary Bone Cells: Osteoclasts, Osteoblasts, and Osteocytes Fracture Healing and Graft Consolidation Autogenous Bone Harvesting Techniques Optimal Instrumentation for Autograft Harvesting Clinical Uses and Indications for Autogenous Bone Future Research Investigating Bone Conditioned Media Conclusion References 03: The Use of Allografts for Bone and Periodontal Regeneration Summary Biologic Background Physical and Biologic Properties Clinical Indications for Allografts and Case Presentations of Bone Regeneration Key Principles Conclusion References 04: The Use of Xenografts in Implant Dentistry and Periodontology Summary Biologic Background of Nonresorbable Materials Clinical Indications and Case Presentations Using DBBM for Bone Regeneration Clinical Indications and Case Presentations Using DBBM for Periodontal Regeneration Conclusion References 05: Next-Generation Natural Bovine Bone Mineral Grafting Material with Integrated Atelocollagen Type 1 Summary Biologic Background Additional Literature Supporting the Use of Atelocollagen Clinical Indications for ABBM and Presented Clinical Cases Conclusion References 06: Synthetic Bone Substitute Materials Summary Nomenclature of Synthetic Biomaterials Biologic Background: Selecting Synthetic Materials Resorption Hydroxyapatite Calcium Phosphosilicate b-Tricalcium Phosphate Biphasic Calcium Phosphates Synthetic Polymers Titanium Granules Material Surface and Structure Clinical Indications and Case Presentations of Bone Regeneration Conclusion References 07: Next-Generation Osteoinductive Synthetic Calcium Phosphates: Osopia Summary Modifications in the Fabrication of Synthetic Calcium Phosphates Comparing Osopia to Autografts, Allografts, and Xenografts Clinical Indications for Osopia Conclusion References 08: The Use of Autogenous Dentin Particulate Graft for Alveolar Ridge Preservation and Augmentation Following Tooth Extraction Summary Selecting a Scaffold for Optimal Wound Healing and Bone Deposition Use of Extracted Tooth Dentinfor Ridge Preservation From Extracted Tooth toAutogenous Particulate Dentin Clinical Cases Conclusion References 09: Next-Generation Osteoconductive Resorbable Bone Adhesives: Tetranite Summary Development of Load-Bearing Bone Grafts Composition Mechanical Properties Benchtop Mechanical Characterization Exploration of Potential Dental Applications Consequences of Exposed TN Grafts in Critical-Size Defects Formulation Variants Conclusion References 10: 3D Printing Scaffolds for Alveolar Bone Augmentation Summary 3D Printing Background 3D Bioprinting Technique Printing Materials Conclusion References 11: Membranes for Guided Tissue and Bone Regeneration Summary Principles of Guided Tissue and Bone Regeneration Types of Membranes for GTRand GBR Clinical Cases Utilizing Barrier Membranes Current Trends in the Development of Membranes Conclusion References 12: Autogenous Blood-Derived Barrier Membranes: Platelet-Rich Fibrin in Regenerative Dentistry Summary Brief History of Platelet Concentrates: From PRP to PRF The Low-Speed Centrifugation Concept Clinical Use of PRF and Its Indications Conclusion References 13: Bone Regeneration with Bone Morphogenetic Protein 2 Summary Biologic Background Clinical Indications for rhBMP-2 Conclusion References 14: Enamel Matrix Derivative: Preclinical Biologic Background Summary Biology of Periodontal Regeneration with Enamel Matrix Proteins Animal and Human Histologic Evidence of Periodontal Regeneration with the Use of EMD Future Perspectives Conclusion References 15: Enamel Matrix Derivative: Clinical Studies Summary Safety of EMD Effects on Early Wound Healing Clinical Outcomes Following Nonsurgical Periodontal Therapy Clinical Outcomes in Intrabony Defects Clinical Outcomes in Recession Defects Using EMD Alone or as Adjunct to Soft Tissue Grafting Clinical Outcomes with EMD in Furcation Defects Clinical Treatment Guidelines for EMD Future Research Conclusion References 16: Efficacy of Recombinant Human PDGF and FGF-2 for Regenerative Dentistry Summary Biologic Background Supporting Literature Clinical Indications and Cases Conclusion References 17: Combination Approaches for Periodontal Regeneration: Biologics, Bone Grafts, and Barrier Membranes Summary Biologic Agents and Growth Factors for Periodontal Regeneration Role of Grafting Materials in Periodontal Regeneration Role of Barrier Membranes in Periodontal Regeneration Combination of Biologics and Grafting Materials Combination of Biologic Agents/Growth Factors andMembranes Combination of Grafting Materials with Membranes Conclusion References 18: Next-Generation Bone Morphogenetic Protein 9: The Future of Bone Regeneration? Summary Biologic Background: Adenovirus Transfection Experiments Biologic Background: rhBMP Experiments Clinical Indications for rhBMP-9 Literature Supporting the Different Pathway for BMP-9 Conclusion References 19: Osteogain: The Next Generation of Enamel Matrix Derivative Summary Biologic Background and Development Study 1: Protein Adsorption of EMD Gel Versus EMD Liquid Study 2: Optimizing the Physicochemical Properties of EMD Study 3: Osteogain Increases Osteoblast and PDL Cell Proliferation and Differentiation Study 4: Gene Array of PDL Cells Exposed to Osteogain in Combination with a Bone Grafting Material Study 5: Bone Grafting Material in Combination with Osteogain for Bone Repair Study 6: Use of Osteogain for the Regeneration of Periodontal Tissue in Intrabony and Furcation Defects Conclusion References 20: Next-Generation Wound Healing with Hyaluronic Acid Summary Mechanism of HA Action for Wound Healing Effect of HA on Bone Regeneration Periodontal Regeneration with HA Conclusion References 21: Next-Generation Ion Incorporation into Bone Grafts for Bone and Periodontal Regeneration Summary The Development of Bioactive Glasses The Mechanism for MBGRelated Bone Regeneration Preparation of MBG Preparation of Ions Incorporated into MBGs Utilization and Effects of Different Therapeutic Ions Conclusion References 22: Next-Generation Use of Gene Therapy for Growth Factor Delivery Summary Biologic Background of Gene Therapy Gene Therapy in Bone Regeneration Target Genes Scaffolds Conclusion References 23: Clinical Recommendations and Guidelines for Selecting Biomaterials for Bone and Periodontal Regeneration Summary Extraction Sockets Sinus Augmentation Guided Bone Regeneration Immediate Implant Dentistry Next-Generation Biomaterials for Bone Regeneration Periodontal Regeneration o fIntrabony and Furcation Defects Patients with Systemic Conditions Conclusion References Abbreviations Index With contributions from Dr Richard J. Miron Dr Yufeng Zhang